Actual research :

Research on insecticide resistance in mosquitoes.

Mosquitoes transmit numerous human and animal diseases and their control represents a public health challenge and an important risk factor worldwide. Dengue and yellow fever viruses are both transmitted by Aedes mosquitoes. Because vaccines against these diseases are not available or not efficiently used, limiting their transmission is highly dependent on vector control activities. In consequence of climate change and increased economical exchanges, the geographic living area of several vectors are extending. In high disease prevalence regions, mosquito control relies essentially on the use of chemical insecticides and this strategy has been successfully used for malaria eradication in metropolitan France during the XXth century. However, resistance to all classes of conventional insecticides is now threatening vector control programs. Resistance to an insecticide can be the consequence of a mutation of the mosquito target protein (target-site resistance), its lower penetration (cuticle resistance) and its bio-degradation or sequestration by mosquito detoxification enzymes (metabolic resistance).

to investigate the mechanisms of insecticides resistance in Aedes aegyti, strains of mosquitoes have selected since several generation to obtain a significant resistance to insecticides. Transcriptome analyses have been realized and revealed an over-transcription of genes encoding cuticle proteins and detoxification enzymes in the resistant strains.

To validate the implication of theses candidate proteins in the metabolic and cuticular resistance and to evaluate the cross-resistance level, I combine different techniques from ecotoxicology, biochemistry, histology and genetics.

CV :     Pdf

Research experience :
Ph.D. (2007-2011) University of Grenoble, Albert Bonniot's Institute (UMR Inserm/UJF U823).
Title : About cell migration and cellular response to the physical properties of the extracellular matrix : ICAP-1 regulates integrins and cell contractility.
The Ph.D. Dissertation (in French) is available on the web site “TEL“ (thesis on line) :
http://tel.archives-ouvertes.fr/tel-00622918

Teaching experience :
mainly about molecular and cell biology, biotechnology, in Joseph Fourier's University, Grenoble, France.
• In the pharmacy unit (2010-2012 :
     - “biotechnology” program (2nd and 4th year university students)
     - “pharmacy” program (2nd year university students).
• In the biology unit (2007-2010) :
     - “biology”, “bio-informatics” “life and Earth sciences” programs (1st to 3rd         year university students)
     -“life and Earth sciences teacher formation” program.

Publication :    

Régent M., Planus E., Bouin A-P., Bouvard D., Brunner M., Faurobert E., Millon-Frémillon A., Block M.R., Albiges-Rizo C. Specicites of beta1 integrin signaling in the control of cell adhesion and adhesive strength. European Journal of Cell Biology. 90(2-3) :261-269, feb-march 2011.