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XPADE: Research fields

by Webmaster - 3 May 2016 ( last update : 25 August 2016 )

XPADE: Xenobiotic Pressure: Adaptation and Dysfunction of Ecosystems

XPADE addresses three major challenges which are:

1) How can we realistically elucidate the impacts of xenobiotics at the organism and sub-organism levels? The correlation between exposure to xenobiotics and their effects will be investigated at the organism (toxicity, resistance, body size, growth fecundity…) and sub-organism (gene expression, endocrine disruptions…) levels. The challenge is to understand the mechanisms involved in phenotypic plasticity in the presence of (i) realistic multi-pollution pressures and (ii) natural parameter variability (UV, temperature…). The integration of cross-effects on organism responses will be essential (i) to highlight confounding factors and (ii) to predict effects of population dynamics at large-scale systems using modelling tools.

2) How can we estimate the long-term impacts of pollutants in controlled conditions? The assessment of large-scale effects of ubiquitous pollutant mixtures (at realistic environmental levels) will be studied at a multigenerational scale. Such exposures are rarely studied mainly for practical reasons with consequently few datasets on the adaptive processes in a population. We recently developed two types of multigenerational studies: one in microcosms (insects with short generation time) and another in mesocosms (trans-generational studies on long-life cycle models as amphibians).

3) How can we estimate the effect of pollutants in a world with multiple environmental stresses?
The patterns of abundance, distribution, diversity and adaptation will be investigated in the presence of realistic xenobiotic pressures located in very well defined natural areas. The (meta)datasets obtained from these approaches will highlight adaptation of local species to the combined criteria of xenobiotics, environmental parameters and temporal variability. These species will be of interest for (i) studying the mechanisms involved in the tolerance to chemicals and (ii) exploiting them in remediation processes. Such a holistic top-down approach will provide accurate large-scale predictions of ecosystem alterations induced by xenobiotic pressures.

Contacts:
Muriel Raveton: muriel.raveton[at]univ-grenoble-alpes.fr
Stéphane Reynaud: stephane.reynaud[at]univ-grenoble-alpes.fr




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